Who is at risk of developing osteoporosis

Anyone can develop osteoporosis, but women are at higher risk than men.

In both men and women, the risk of osteoporosis goes up with age, with bone loss usually starting slowly around age 30. For men, bone loss tends to occur gradually over time, while women experience a period of heightened bone loss around menopause that then slows down again after a few years.

Thin people with small bones are at the highest risk of osteoporosis. And this relates to another reason women experience higher rates of osteoporosis than men: they often simply begin with less bone mass.
Of all racial and ethnic groups, African Americans tend to be at the lowest risk, but all races and ethnicities suffer from osteoporosis.

Role of Calcium & Calcium Absorption:

  • Calcium is the cornerstone of osteoporosis treatment.
  • About 25 mmolof calcium enters the body in a normal diet. Of this, about 40% (10 mmol) is absorbed in small intestines and 5 mmol leaves the body in feces, netting 5 mmol of calcium a day.
  • Calcium is absorbed inside the body across the intestinal membrane, passing through ion channels. Calbindin is a vitamin D-dependent calcium-binding protein inside intestinal epithelial cells which functions together with calcium pumps in the basal membrane to actively transport calcium into the body. Active transport of calcium occurs primarily in the duodenum  portion of the intestine when calcium intake is low; and through passive paracellular transport occurs in the parts of the small intestine when
  • calcium intake is high, independent of Vitamin D level.

Excretion The kidney excretes 250 mmol, a day in pro-urine, and resorbs 245 mmol, leading to a net loss in the urine of 5 mmol/d. In addition to this, the kidney processes Vitamin D into calcitrol the active form that is most effective in assisting intestinal absorption. Both processes are stimulated by parathyroid hormone.

OSTEOPOROSIS: Symptoms and Warning Signs of Osteoporosis?

Bone loss can continue for many years without causing any symptoms, so many people with osteoporosis don't know they have it. Sometimes the first symptom is a broken bone.

  • Vertebra (bones in the back) can break leading to pain, loss of height, or back deformities.
  • Hip fractures can lead to pain, surgery, disability and even death.
  • Fractures of the wrist and other bones can also lead to pain, hospitalization and disability.

 

That's why preventing osteoporosis is important.
Recurrent fractures.
Fracture from minimal trauma.
Experiencing chronic medical problems.

Who should be screened for Osteoporosis?

There are no ‘specific’ screening tests to identify people who will develop bone loss and fractures.

However, if a patient has high osteoporosis risk factors or symptoms, there are tests (like x-rays and bone scans) The doctor can do these to see if the patient has had bone loss.

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